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The .405 Winchester (also known as the .405 WCF) is a centerfire rifle cartridge introduced in 1904 for the Winchester 1895 lever-action rifle. It remains to this day one of the most powerful rimmed cartridge designed specifically for lever-action rifles; the only modern lever action cartridges that exceed its performance are the .50 Alaskan, .450 Alaskan, .475 Turnbull, .348 Turnbull and the .450 Marlin. The .405 was highly regarded by U.S. President Theodore Roosevelt during his safari in East Africa.

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